TP-003

TP-003

Systematic (IUPAC) name
5-fluoro-2-[4-fluoro-3-[8-fluoro-7-(2-hydroxypropan-2-yl)imidazo[1,2-a]pyridin-3-yl]phenyl]benzonitrile
Identifiers
CAS Number	628690-75-5 N
PubChem	CID: 9978724
ChemSpider	8177015 Y
Chemical data
Formula	C23H16F3N3O
Molecular mass	407.387 g/mol
SMILES CC(C)(C1=C(C2=NC=C(N2C=C1)C3=C(C=CC(=C3)C4=C(C=C(C=C4)F)C#N)F)F)O
InChI InChI=1S/C23H16F3N3O/c1-23(2,30)18-7-8-29-20(12-28-22(29)21(18)26)17-10-13(3-6-19(17)25)16-5-4-15(24)9-14(16)11-27/h3-10,12,30H,1-2H3 Y Key:VLFITPUZJCLTFQ-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

TP-003 is an anxiolytic drug with a novel chemical structure, which is used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. It is a subtype-selective partial agonist at GABA_A receptors, binding to GABA_A receptor complexes bearing either α₂, α₃ or α₅ subunits, but only showing significant efficacy at α₃. It has modest anticonvulsant activity although less than that of diazepam, and its main effect is likely to be selective anxiolytic action, as seen with other related α₃-preferring agonists such as L-838,417.

See also

• Imidazopyridine