Tomas Lindahl

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Tomas Lindahl
Tomas Lindahl 0113.jpg
Tomas Lindahl at the Royal Swedish Academy of Sciences (2015)
Born Tomas Robert Lindahl
(1938-01-28) 28 January 1938 (age 84)[1]
Stockholm, Sweden
Nationality Swedish, naturalised British
(dual nationality)
Fields
Institutions
Alma mater
Thesis On the structure and stability of nucleic acids in solution (1967)
Known for Clarification of cellular resistance to carcinogens
Influences Walter Bodmer
Notable awards
Website
crick.ac.uk/research/a-z-researchers/emeritus-scientists/tomas-lindahl/

Tomas Robert Lindahl FRS[3] FMedSci[4] (born 28 January 1938) is a Swedish-born British scientist specialising in cancer research.[5]

In 2015, he was awarded the Nobel Prize in Chemistry[6] jointly with American chemist Paul L. Modrich and Turkish chemist Aziz Sancar for mechanistic studies of DNA repair.[7][8][9]

Education

Lindahl was born in Kungsholmen, Stockholm, Sweden to Folke Robert Lindahl and Ethel Hulda Hultberg.[10] He received a PhD degree in 1967,[11] and an MD degree qualification in 1970, from the Karolinska Institutet in Stockholm.[1]

Career

After obtaining his research doctorate, Lindahl did postdoctoral research at Princeton University and Rockefeller University.[12] He was professor of medical chemistry at the University of Gothenburg 1978–82. After moving to the United Kingdom he joined the Imperial Cancer Research Fund (now Cancer Research UK) as a researcher in 1981.[12] From 1986 to 2005 he was the first Director of Cancer Research UK's Clare Hall Laboratories in Hertfordshire, since 2015 part of the Francis Crick Institute.[13] He continued to research there until 2009.

He has contributed to many papers on DNA repair and the genetics of cancer.[14][15][16][17][18][19][20][21][22]

Awards and honours

Lindahl received the Royal Society's Royal Medal in 2007 "making fundamental contributions to our understanding of DNA repair. His achievements stand out for their great originality, breadth and lasting influence."[23] He is a member of the Norwegian Academy of Science and Letters.[24] He was awarded the Copley Medal in 2010. He was elected a founding Fellow of the Academy of Medical Sciences (FMedSci) in 1998. He was elected a Fellow of the Royal Society (FRS) in 1988,[25] his certificate of election reads:

He shared the Nobel Prize in Chemistry in 2015.[7] The Swedish Academy noted that "The Nobel Prize in Chemistry 2015 was awarded jointly to Tomas Lindahl, Paul Modrich and Aziz Sancar 'for mechanistic studies of DNA repair'."[26]

References

  1. ↑ 1.0 1.1 LINDAHL,. Who's Who. 2015 (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles> (subscription required)
  2. ↑ Lindahl, Tomas (2013). "My Journey to DNA Repair". Genomics, Proteomics & Bioinformatics. 11 (1): 2–7. doi:10.1016/j.gpb.2012.12.001. ISSN 1672-0229.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  3. ↑ 3.0 3.1 3.2 "Lindahl, Tomas Robert: EC/1988/20". London: The Royal Society. Archived from the original on 2014-11-21.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  4. ↑ 4.0 4.1 "Dr Tomas Lindahl FRS FMedSci". London: Academy of Medical Sciences. Archived from the original on 2015-10-08.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  5. ↑ "Emeritus Scientist - Tomas Lindahl". The Crick. Archived from the original on 2015-12-01.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  6. ↑ Tomas Lindahl - Nobel Prize in Chemistry 2015 on Vimeo
  7. ↑ 7.0 7.1 Broad, William J. (2015-10-07). "Nobel Prize in Chemistry Awarded to Tomas Lindahl, Paul Modrich and Aziz Sancar for DNA Studies". The New York Times. ISSN 0362-4331. Retrieved 2015-10-07.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  8. ↑ Staff (7 October 2015). "THE NOBEL PRIZE IN CHEMISTRY 2015 – DNA repair – providing chemical stability for life" (PDF). Nobel Prize. Retrieved 7 October 2015.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  9. ↑ Cressey, Daniel (2015). "DNA repair sleuths win chemistry Nobel: Tomas Lindahl, Paul Modrich and Aziz Sancar share 2015 prize". Nature. 526 (7573): 307–8. doi:10.1038/nature.2015.18515. ISSN 1476-4687. PMID 26469021.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  10. ↑ Sweden, Indexed Birth Records, 1860–1941
  11. ↑ Lindahl, Tomas (1967). On the structure and stability of nucleic acids in solution. Stockholm.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  12. ↑ 12.0 12.1 "Cancer Research UK Grants & Research – Tomas Lindahl". Retrieved 2008-11-10.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  13. ↑ "4 ways that Tomas Lindahl’s Nobel Prize for Chemistry revolutionised cancer research", by Emma Smith, CRUK Science blog, October 7, 2015
  14. ↑ Gerken, T. is; Girard, C. A.; Tung, Y. -C. L.; Webby, C. J.; Saudek, V.; Hewitson, K. S.; Yeo, G. S. H.; McDonough, M. A.; Cunliffe, S.; McNeill, L. A.; Galvanovskis, J.; Rorsman, P.; Robins, P.; Prieur, X.; Coll, A. P.; Ma, M.; Jovanovic, Z.; Farooqi, I. S.; Sedgwick, B.; Barroso, I.; Lindahl, T.; Ponting, C. P.; Ashcroft, F. M.; O'Rahilly, S.; Schofield, C. J. (2008). "The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase". Science. 318 (5855): 1469–1472. doi:10.1126/science.1151710. PMC 2668859. PMID 17991826.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  15. ↑ Tomas Lindahl's publications indexed by the Scopus bibliographic database, a service provided by Elsevier.
  16. ↑ Lindahl, T. (1993). "Instability and decay of the primary structure of DNA". Nature. 362 (6422): 709–15. doi:10.1038/362709a0. PMID 8469282.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  17. ↑ Wood, R. D. (2001). "Human DNA Repair Genes". Science. 291 (5507): 1284–9. doi:10.1126/science.1056154. PMID 11181991.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  18. ↑ Satoh, M. S.; Lindahl, T. (1992). "Role of poly(ADP-ribose) formation in DNA repair". Nature. 356 (6367): 356. doi:10.1038/356356a0. PMID 1549180.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  19. ↑ Trewick, S. C.; Henshaw, T. F.; Hausinger, R. P.; Lindahl, T; Sedgwick, B (2002). "Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage". Nature. 419 (6903): 174–8. doi:10.1038/nature00908. PMID 12226667.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  20. ↑ Barnes, D. E.; Lindahl, T (2004). "Repair and genetic consequences of endogenous DNA base damage in mammalian cells". Annual Review of Genetics. 38: 445–76. doi:10.1146/annurev.genet.38.072902.092448. PMID 15568983.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  21. ↑ Yang, Y. G.; Lindahl, T; Barnes, D. E. (2007). "Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease". Cell. 131 (5): 873–86. doi:10.1016/j.cell.2007.10.017. PMID 18045533.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  22. ↑ Crow, Y. J.; Hayward, B. E.; Parmar, R; Robins, P; Leitch, A; Ali, M; Black, D. N.; Van Bokhoven, H; Brunner, H. G.; Hamel, B. C.; Corry, P. C.; Cowan, F. M.; Frints, S. G.; Klepper, J; Livingston, J. H.; Lynch, S. A.; Massey, R. F.; Meritet, J. F.; Michaud, J. L.; Ponsot, G; Voit, T; Lebon, P; Bonthron, D. T.; Jackson, A. P.; Barnes, D. E.; Lindahl, T (2006). "Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus". Nature Genetics. 38 (8): 917–20. doi:10.1038/ng1845. PMID 16845398.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  23. ↑ "Royal recent winners". Retrieved 2008-11-10.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  24. ↑ "Gruppe 6: Cellebiologi og molekylærbiologi" (in Norwegian). Norwegian Academy of Science and Letters. Retrieved 7 October 2010.CS1 maint: unrecognized language (link)<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  25. ↑ "Dr Tomas Lindahl FMedSci FRS". London: Royal Society. Archived from the original on 2015-09-22.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  26. ↑ "The Nobel Prize in Chemistry 2015". nobelprize.org.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
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