UPB1

Ureidopropionase, beta
Identifiers
Symbols	UPB1 ; BUP1
External IDs	OMIM: 606673 MGI: 2143535 HomoloGene: 9471 GeneCards: UPB1 Gene
EC number	3.5.1.6
Gene ontology Molecular function • beta-ureidopropionase activity • metal ion binding Cellular component • cytosol • extracellular exosome Biological process • pyrimidine nucleobase metabolic process • beta-alanine biosynthetic process • small molecule metabolic process • pyrimidine nucleoside catabolic process • nucleobase-containing small molecule metabolic process Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE UPB1 220507 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51733	103149
Ensembl	ENSG00000100024	ENSMUSG00000033427
UniProt	Q9UBR1	Q8VC97
RefSeq (mRNA)	NM_016327	NM_133995
RefSeq (protein)	NP_057411	NP_598756
Location (UCSC)	Chr 22: 24.49 – 24.53 Mb	Chr 10: 75.41 – 75.44 Mb
PubMed search	[1]	[2]

Beta-ureidopropionase is an enzyme that in humans is encoded by the UPB1 gene.

This gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

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|{{{bSize}}}px|alt=Fluorouracil (5-FU) Activity edit]]

File:FluoropyrimidineActivity_WP1601.png

Fluorouracil (5-FU) Activity edit