Urapidil

Urapidil

Systematic (IUPAC) name
6-({3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl}amino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ (Prescription only)
Routes of administration	Oral
Identifiers
CAS Number	34661-75-1 64887-14-5 (HCl)
ATC code	C02CA06 (WHO)
PubChem	CID: 5639
ChemSpider	5437
UNII	A78GF17HJS Y
ChEMBL	CHEMBL279229
Chemical data
Formula	C20H29N5O3
Molecular mass	387.48 g/mol
SMILES O=C1\C=C(/N(C(=O)N1C)C)NCCCN3CCN(c2ccccc2OC)CC3

Urapidil is a sympatholytic antihypertensive drug. It acts as an α₁-adrenoceptor antagonist and as an 5-HT_1A receptor agonist Although an initial report suggested that urapidil was also an α₂-adrenoceptor agonist, this was not substantiated in later studies that demonstrated it was devoid of agonist actions in the dog saphenous vein and the guinea-pig ileum. Unlike some other α₁-adrenoceptor antagonists, urapidil does not elicit reflex tachycardia, and this may be related to its weak β₁-adrenoceptor antagonist activity, as well as its effect on cardiac vagal drive. Urapidil is currently not approved by the U.S. Food and Drug Administration, but it is available in Europe.

See also

• Naftopidil