ZEB1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.[1][2][3]
ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site.[3][4] ZEB1 and its mammalian paralog ZEB2 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors. ZEB1 protein has 7 zinc fingers and 1 homeodomain. [5] The structure of the homeodomain shown on the right.
Clinical significance
Mutations of the gene are linked to posterior polymorphous corneal dystrophy 3. A recent study suggested its contributing role in lung cancer invasiveness and metastasis development.[6]
References
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Further reading
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External links
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