ZK-93426

ZK-93426

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Names
IUPAC name ethyl 5-​isopropoxy-​4-​methyl-​9H-​β-​carboline-​3-​carboxylate
Other names ZK-93426; ethyl 4-methyl-5-propan-2-yloxy-9H-pyrido[5,4-b]indole-3-carboxylate
Identifiers
CAS Number	89592-45-0 Y
ChEMBL	ChEMBL1271047 N
ChemSpider	103086 N
IUPHAR/BPS	4347
Jmol 3D model	Interactive image
PubChem	115210
InChI InChI=1S/C18H20N2O3/c1-5-22-18(21)17-11(4)15-13(9-19-17)20-12-7-6-8-14(16(12)15)23-10(2)3/h6-10,20H,5H2,1-4H3 N Key: VMDUABMKBUKKPG-UHFFFAOYSA-N N InChI=1/C18H20N2O3/c1-5-22-18(21)17-11(4)15-13(9-19-17)20-12-7-6-8-14(16(12)15)23-10(2)3/h6-10,20H,5H2,1-4H3 Key: VMDUABMKBUKKPG-UHFFFAOYAG
SMILES CCOC(=O)C1=NC=C2C(=C1C)C3=C(N2)C=CC=C3OC(C)C
Properties
Chemical formula	C18H20N2O3
Molar mass	314.336 g/mol
Vapor pressure	{{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

ZK-93426 (ethyl-5-isopropoxy-4-methyl-beta-carboline-3-carboxylate) is a drug from the beta-carboline family. It acts as a weak partial inverse agonist of benzodiazepine receptors, meaning that it causes the opposite effects to the benzodiazepine class of drugs and has anxiogenic properties, although unlike most benzodiazepine antagonists it is not a convulsant and actually has weak anticonvulsant effects. In human tests it produced alertness, restlessness and feelings of apprehension, and reversed the effect of the benzodiazepine lormetazepam. It was also shown to produce nootropic effects and increased release of acetylcholine.

See also

• ZK-93423