Arogenate dehydrogenase (NADP+)

In enzymology, an arogenate dehydrogenase (NADP+) (EC 1.3.1.78) is an enzyme that catalyzes the chemical reaction

L-arogenate + NADP⁺ $\rightleftharpoons$ L-tyrosine + NADPH + CO₂

Thus, the two substrates of this enzyme are L-arogenate and NADP⁺, whereas its 3 products are L-tyrosine, NADPH, and CO₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-arogenate:NADP+ oxidoreductase (decarboxylating). Other names in common use include arogenic dehydrogenase (ambiguous), pretyrosine dehydrogenase (ambiguous), TyrAAT1, TyrAAT2, and TyrAa.