CCL11

Chemokine (C-C motif) ligand 11
PDB rendering based on 1eot.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1EOT, 2EOT, 2MPM
Identifiers
Symbols	CCL11 ; SCYA11
External IDs	OMIM: 601156 MGI: 103576 HomoloGene: 7929 GeneCards: CCL11 Gene
Gene ontology Molecular function • protein binding • chemokine activity • CCR chemokine receptor binding Cellular component • extracellular region • extracellular space • intracellular • cell Biological process • positive regulation of endothelial cell proliferation • chronic inflammatory response • monocyte chemotaxis • mast cell chemotaxis • protein phosphorylation • cellular calcium ion homeostasis • chemotaxis • inflammatory response • cytoskeleton organization • actin filament organization • cell adhesion • signal transduction • G-protein coupled receptor signaling pathway • regulation of cell shape • response to radiation • response to virus • positive regulation of cell migration • neutrophil chemotaxis • positive regulation of actin filament polymerization • response to interleukin-13 • positive regulation of GTPase activity • positive regulation of angiogenesis • eosinophil chemotaxis • lymphocyte chemotaxis • branching involved in mammary gland duct morphogenesis • mammary duct terminal end bud growth • chemokine-mediated signaling pathway • ERK1 and ERK2 cascade • positive regulation of ERK1 and ERK2 cascade • response to interleukin-4 • cellular response to interferon-gamma • cellular response to interleukin-1 • cellular response to tumor necrosis factor Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6356	20292
Ensembl	ENSG00000172156	ENSMUSG00000020676
UniProt	P51671	P48298
RefSeq (mRNA)	NM_002986	NM_011330
RefSeq (protein)	NP_002977	NP_035460
Location (UCSC)	Chr 17: 34.29 – 34.29 Mb	Chr 11: 82.06 – 82.06 Mb
PubMed search	[1]	[2]

C-C motif chemokine 11 also known as eosinophil chemotactic protein and eotaxin-1 is a protein that in humans is encoded by the CCL11 gene. This gene is encoded on three exons and is located on chromosome 17.

Function

CCL11 is a small cytokine belonging to the CC chemokine family. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which CCL11 is a ligand include CCR2, CCR3 and CCR5. However, it has been found that eotaxin-1 (CCL11) has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3.

Clinical significance

Increased CCL11 levels in blood plasma are associated with aging in mice and humans. Additionally, it has been demonstrated that exposing young mice to CCL11 or the blood plasma of older mice decreases their neurogenesis and cognitive performance on behavioural tasks thought to be dependent on neurogenesis in the hippocampus.

Higher plasma concentrations of CCL11 have been found in current cannabis users compared to past users and those who had never used. CCL11 has also been found in higher concentrations in people suffering from schizophrenia; cannabis is a known trigger of schizophrenia.