FGF3

Fibroblast growth factor 3
Identifiers
Symbols	FGF3 ; HBGF-3; INT2
External IDs	OMIM: 164950 MGI: 95517 HomoloGene: 3841 GeneCards: FGF3 Gene
Gene ontology Molecular function • fibroblast growth factor receptor binding • protein binding • growth factor activity Cellular component • extracellular region • Golgi apparatus Biological process • organ induction • signal transduction • epidermal growth factor receptor signaling pathway • cell-cell signaling • positive regulation of cell proliferation • insulin receptor signaling pathway • fibroblast growth factor receptor signaling pathway • anatomical structure morphogenesis • otic vesicle formation • post-anal tail morphogenesis • Fc-epsilon receptor signaling pathway • innate immune response • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • thymus development • semicircular canal morphogenesis • positive regulation of cell division • negative regulation of cardiac muscle tissue development Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE FGF3 214571 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2248	14174
Ensembl	ENSG00000186895	ENSMUSG00000031074
UniProt	P11487	P05524
RefSeq (mRNA)	NM_005247	NM_008007
RefSeq (protein)	NP_005238	NP_032033
Location (UCSC)	Chr 11: 69.81 – 69.82 Mb	Chr 7: 144.84 – 144.84 Mb
PubMed search	[1]	[2]

INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene.

Function

FGF-3 is a member of the fibroblast growth factor family. FGF3 binds to Fibroblast Growth Factor Receptor 3 (FGFR3) to serve as a negative regulator of bone growth during ossification. Effectively, FGF-3 inhibits proliferation of chondrocytes within growth plate.

FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.

Clinical significance

The FGF3 gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. Also, haploinsufficiency in the FGF3 gene is thought to cause otodental syndrome.

Interactions

FGF3 (gene) has been shown to interact with EBNA1BP2.