FRAX
FRAX is a diagnostic tool used to evaluate the 10-year probability of bone fracture risk. It was developed by the World Health Organization Collaborating Centre for Metabolic Bone Diseases at Sheffield University.[1] FRAX integrates clinical risk factors and bone mineral density at the femoral neck to calculate the 10-year probability of hip fracture and the 10-year probability of a major osteoporotic fracture (clinical spine, forearm, hip or shoulder fracture).[2]
FRAX is freely accessible online, and commercially available as a desktop application, in paper-form as a FRAX Pad, as an iPhone application, and as an Android application. The tool is compatible with 58 models for 53 countries, and is available in 28 languages.[1]
The models used to develop the FRAX diagnostic tool were derived from studying patient populations in North America, Europe, Latin America, Asia and Australia.[3] Clinical risk factors assessed include a prior fragility fracture, parental history of hip fracture, current tobacco smoking, long-term use of glucocorticoids, rheumatoid arthritis, other causes of secondary osteoporosis and daily alcohol consumption. FRAX assessments are intended to provide guidance for determining access to treatment in healthcare systems.[4]
FRAX is incorporated into many national guidelines around the world, including those of Belgium, Canada, Japan, Netherlands, Poland, Sweden, Switzerland, UK (NOGG), and US (NOF).
References
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