FTH1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Ferritin heavy chain is a ferroxidase enzyme that in humans is encoded by the FTH1 gene.[1][2]
Function
This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined.[2]
Interactions
FTH1 has been shown to interact with Ferritin light chain.[3][4]
See also
References
Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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