HYAL3

Hyaluronoglucosaminidase 3
Identifiers
Symbols	HYAL3 ; HYAL-3; LUCA-3; LUCA3
External IDs	OMIM: 604038 MGI: 1330288 HomoloGene: 2626 GeneCards: HYAL3 Gene
EC number	3.2.1.35
Gene ontology Molecular function • virus receptor activity • hyalurononglucosaminidase activity • protein binding • hyaluronoglucuronidase activity Cellular component • extracellular region • lysosome • cytoplasmic vesicle Biological process • carbohydrate metabolic process • inflammatory response • response to virus • hyaluronan catabolic process • response to antibiotic • cartilage development • cellular response to interleukin-1 • cellular response to tumor necrosis factor • cellular response to UV-B Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8372	109685
Ensembl	ENSG00000186792	ENSMUSG00000036091
UniProt	O43820	Q8VEI3
RefSeq (mRNA)	NM_001200029	NM_178020
RefSeq (protein)	NP_001186958	NP_821139
Location (UCSC)	Chr 3: 50.29 – 50.3 Mb	Chr 9: 107.58 – 107.59 Mb
PubMed search	[1]	[2]

Hyaluronidase-3 is an enzyme that in humans is encoded by the HYAL3 gene.

This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression.