Hydroperoxide dehydratase

hydroperoxide dehydratase
Identifiers
EC number	4.2.1.92
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a hydroperoxide dehydratase (EC 4.2.1.92) is an enzyme that catalyzes the chemical reaction

(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate $\rightleftharpoons$ (9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate + H₂O

Hence, this enzyme has one substrate, (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate, and two products, (9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]. Other names in common use include hydroperoxide isomerase, linoleate hydroperoxide isomerase, linoleic acid hydroperoxide isomerase, HPI, (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate, and 12,13-hydro-lyase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1U5U.