MRPL37

Mitochondrial ribosomal protein L37
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Symbols	MRPL37 ; L37mt; MRP-L2; MRP-L37; MRPL2; RPML2
External IDs	OMIM: 611843 MGI: 1926268 HomoloGene: 9536 GeneCards: MRPL37 Gene
Gene ontology Molecular function • structural constituent of ribosome • poly(A) RNA binding Cellular component • mitochondrion • mitochondrial inner membrane • mitochondrial ribosome Biological process • translation • organelle organization • mitochondrial translation • mitochondrial translational initiation • mitochondrial translational elongation • mitochondrial translational termination Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51253	56280
Ensembl	ENSG00000116221	ENSMUSG00000028622
UniProt	Q9BZE1	Q921S7
RefSeq (mRNA)	NM_016491	NM_025500
RefSeq (protein)	NP_057575	NP_079776
Location (UCSC)	Chr 1: 54.18 – 54.23 Mb	Chr 4: 107.06 – 107.07 Mb
PubMed search	[1]	[2]

39S ribosomal protein L37, mitochondrial is a protein that in humans is encoded by the MRPL37 gene.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.