N-myc-interactor
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). N-myc-interactor also known as N-myc and STAT interactor is a protein that in humans is encoded by the NMI gene.[1][2][3]
Function
NMYC interactor (NMI) interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL-2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias.[3]
Interactions
NMI (gene) has been shown to interact with BRCA1,[4] IFI35,[5] Myc,[4] and STAT5A,[2] and TUBA3C.[6]
References
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Further reading
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