Nadrian Seeman

The M. C. Escher woodcut Depth (pictured) inspired Nadrian Seeman to consider using three-dimensional lattices of DNA to orient hard-to-crystallize molecules. This led to the beginning of the field of DNA nanotechnology.

Nadrian C. "Ned" Seeman (born December 16, 1945) is an American nanotechnologist and crystallographer known for inventing the field of DNA nanotechnology.

Seeman studied biochemistry at the University of Chicago and crystallography at the University of Pittsburgh. He became a faculty member at the State University of New York at Albany, and in 1988 moved to the Department of Chemistry at New York University.

He is most noted for his development of the concept of DNA nanotechnology beginning in the early 1980s. In fall 1980, while at a campus pub, Seeman was inspired by the M. C. Escher woodcut Depth to realize that a three-dimensional lattice could be constructed from DNA. He realized that this could be used to orient target molecules, simplifying their crystallographic study by eliminating the difficult process of obtaining pure crystals. In pursuit of this goal, Seeman's laboratory published the synthesis of the first three-dimensional nanoscale object, a cube made of DNA, in 1991. This work won the 1995 Feynman Prize in Nanotechnology.

The concepts of DNA nanotechnology later found further applications in DNA computing, DNA nanorobotics, and self-assembly of nanoelectronics. He shared the Kavli Prize in Nanoscience 2010 with Donald Eigler “for their development of unprecedented methods to control matter on the nanoscale.” The goal of demonstrating designed three-dimensional DNA crystals was achieved by Seeman in 2009, nearly thirty years after his original elucidation of the idea.

He is a fellow of the Norwegian Academy of Science and Letters

Notable publications

• —Considered to be the earliest paper outlining the concepts of DNA nanotechnology
• —The synthesis of the DNA cube
• —The synthesis of two-dimensional periodic lattices of double crossover molecules
• —The first DNA-based nanomechanical device
• —A popular science article explaining the field of DNA nanotechnology
• —The synthesis of three-dimensional periodic lattices of tensegrity triangle molecules
• —A DNA-based molecular assembly line

See also

• History of DNA nanotechnology