Purine imidazole-ring cyclase

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purine imidazole-ring cyclase
Identifiers
EC number 4.3.2.4
CAS number Template:CAS
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a purine imidazole-ring cyclase (EC 4.3.2.4) is an enzyme that catalyzes the chemical reaction

DNA 4,6-diamino-5-formamidopyrimidine \rightleftharpoons DNA adenine + H2O

Hence, this enzyme has one substrate, DNA 4,6-diamino-5-formamidopyrimidine, and two products, DNA adenine and H2O.

This enzyme belongs to the family of lyases, specifically amidine lyases. The systematic name of this enzyme class is DNA-4,6-diamino-5-formamidopyrimidine C8-N9-lyase (cyclizing DNA-adenine-forming). Other names in common use include DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing), DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing, and DNA-adenine-forming).

References

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