Template:PBB/1392

Corticotropin releasing hormone
PDB rendering based on 1go9.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1GOE, 3EHT, 3EHU
Identifiers
Symbols	CRH ; CRF; CRH1
External IDs	OMIM: 122560 MGI: 88496 HomoloGene: 599 GeneCards: CRH Gene
Gene ontology Molecular function • receptor binding • hormone activity • neuropeptide hormone activity • protein binding • corticotropin-releasing hormone receptor 1 binding • corticotropin-releasing hormone receptor 2 binding Cellular component • extracellular region • extracellular space • cytoplasm • varicosity • perikaryon Biological process • positive regulation of protein phosphorylation • synaptic transmission, dopaminergic • glucocorticoid biosynthetic process • inflammatory response • signal transduction • synaptic transmission • female pregnancy • parturition • learning or memory • positive regulation of cell proliferation • associative learning • hormone-mediated apoptotic signaling pathway • positive regulation of gene expression • negative regulation of gene expression • negative regulation of norepinephrine secretion • positive regulation of circadian sleep/wake cycle, wakefulness • positive regulation of cell death • regulation of serotonin secretion • diterpenoid metabolic process • hypothalamus development • lung development • adrenal gland development • positive regulation of cAMP biosynthetic process • negative regulation of epinephrine secretion • negative regulation of luteinizing hormone secretion • locomotory exploration behavior • positive regulation of insulin secretion involved in cellular response to glucose stimulus • response to immobilization stress • negative regulation of circadian sleep/wake cycle, REM sleep • response to drug • response to estrogen • response to ethanol • response to ether • negative regulation of blood pressure • response to pain • ion homeostasis • response to corticosterone • positive regulation of corticotropin secretion • positive regulation of cortisol secretion • long-term synaptic potentiation • positive regulation of digestive system process • negative regulation of cell death • negative regulation of glucagon secretion • cellular response to cocaine • cellular response to dexamethasone stimulus • positive regulation of calcium ion import • regulation of N-methyl-D-aspartate selective glutamate receptor activity • positive regulation of corticosterone secretion • positive regulation of behavioral fear response Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1392	12918
Ensembl	ENSG00000147571	ENSMUSG00000049796
UniProt	P06850	Q8CIT0
RefSeq (mRNA)	NM_000756	NM_205769
RefSeq (protein)	NP_000747	NP_991338
Location (UCSC)	Chr 8: 66.18 – 66.18 Mb	Chr 3: 19.69 – 19.7 Mb
PubMed search	[1]	[2]