Template:PBB/5366

Phorbol-12-myristate-13-acetate-induced protein 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3MQP
Identifiers
Symbols	PMAIP1 ; APR; NOXA
External IDs	OMIM: 604959 HomoloGene: 88883 GeneCards: PMAIP1 Gene
Gene ontology Molecular function • protein binding Cellular component • nucleus • mitochondrion • mitochondrial outer membrane • cytosol Biological process • release of cytochrome c from mitochondria • apoptotic process • activation of cysteine-type endopeptidase activity involved in apoptotic process • response to UV • response to X-ray • proteasomal protein catabolic process • positive regulation of glucose metabolic process • negative regulation of mitochondrial membrane potential • programmed cell death • positive regulation of protein oligomerization • cellular response to glucose starvation • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • T cell homeostasis • positive regulation of apoptotic process • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • response to dsRNA • positive regulation of DNA damage response, signal transduction by p53 class mediator • positive regulation of neuron apoptotic process • regulation of mitochondrial membrane permeability • negative regulation of fibroblast proliferation • defense response to virus • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • cellular response to hypoxia • intrinsic apoptotic signaling pathway by p53 class mediator • reactive oxygen species metabolic process • positive regulation of release of cytochrome c from mitochondria • intrinsic apoptotic signaling pathway • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • positive regulation of extrinsic apoptotic signaling pathway via death domain receptors • positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • positive regulation of intrinsic apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE PMAIP1 204286 s at tn.png
File:PBB GE PMAIP1 204285 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5366	n/a
Ensembl	ENSG00000141682	n/a
UniProt	Q13794	n/a
RefSeq (mRNA)	NM_021127	n/a
RefSeq (protein)	NP_066950	n/a
Location (UCSC)	Chr 18: 59.9 – 59.9 Mb	n/a
PubMed search	[1]	n/a