AUP1

Ancient ubiquitous protein 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2EKF
Identifiers
Symbol	AUP1
External IDs	OMIM: 602434 MGI: 107789 HomoloGene: 7239 GeneCards: AUP1 Gene
Gene ontology Molecular function • protein binding Cellular component • endoplasmic reticulum membrane • membrane • integral component of membrane • extracellular exosome Biological process • retrograde protein transport, ER to cytosol Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE AUP1 220525 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	550	11993
Ensembl	ENSG00000115307	ENSMUSG00000068328
UniProt	Q9Y679	P70295
RefSeq (mRNA)	NM_181575	NM_001025446
RefSeq (protein)	NP_853553	NP_001288578
Location (UCSC)	Chr 2: 74.53 – 74.53 Mb	Chr 6: 83.05 – 83.06 Mb
PubMed search	[1]	[2]

Ancient ubiquitous protein 1 is a protein that in humans is encoded by the AUP1 gene.

Function

This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25.

Interactions

AUP1 has been shown to interact with ITGA2B.