CBX2 (gene)

Chromobox homolog 2
250px PDB rendering based on 2d9u.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2D9U, 3H91
Identifiers
Symbols	CBX2 ; CDCA6; M33; SRXY5
External IDs	OMIM: 602770 MGI: 88289 HomoloGene: 7256 GeneCards: CBX2 Gene
Gene ontology Molecular function • DNA binding • chromatin binding • protein binding • methylated histone binding Cellular component • euchromatin • heterochromatin • nucleus • nucleoplasm • PcG protein complex • PRC1 complex Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • chromatin modification • protein sumoylation • cell differentiation • post-translational protein modification • cellular protein metabolic process • development of primary sexual characteristics Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE CBX2 215989 at tn.png
File:PBB GE CBX2 gnf1h00861 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	84733	12416
Ensembl	ENSG00000173894	ENSMUSG00000025577
UniProt	Q14781	P30658
RefSeq (mRNA)	NM_005189	NM_007623
RefSeq (protein)	NP_005180	NP_031649
Location (UCSC)	Chr 17: 79.78 – 79.79 Mb	Chr 11: 119.02 – 119.03 Mb
PubMed search	[1]	[2]

Chromobox protein homolog 2 is a protein that in humans is encoded by the CBX2 gene. According to a New Scientist article CBX2 controls human sex even more so than X/Y chromosomes.

Interactions

CBX2 (gene) has been shown to interact with RYBP. It also interacts with the testis determining factor encoded by the SRY gene on the Y chromosome, as both proteins are necessary components of the male cascade.