FLRT3

Fibronectin leucine rich transmembrane protein 3
Identifiers
Symbols	FLRT3 ; HH21
External IDs	OMIM: 604808 MGI: 1918686 HomoloGene: 8322 GeneCards: FLRT3 Gene
Gene ontology Molecular function • receptor signaling protein activity • protein binding, bridging • chemorepellent activity Cellular component • proteinaceous extracellular matrix • extracellular space • intracellular • integral component of plasma membrane Biological process • cell adhesion • axon guidance • biological_process • intracellular signal transduction • negative chemotaxis • positive regulation of synapse assembly Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE FLRT3 219250 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23767	71436
Ensembl	ENSG00000125848	ENSMUSG00000051379
UniProt	Q9NZU0	Q6ZPQ1
RefSeq (mRNA)	NM_013281	NM_001172160
RefSeq (protein)	NP_037413	NP_001165631
Location (UCSC)	Chr 20: 14.32 – 14.34 Mb	Chr 2: 140.65 – 140.67 Mb
PubMed search	[1]	[2]

Leucine-rich repeat transmembrane protein FLRT3 is a protein that in humans is encoded by the FLRT3 gene.

FLRT1, FLRT2 and FLRT3 are members of the fibronectin leucine rich transmembrane protein (FLRT) family. They may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. FLRT3 shares 55% amino acid sequence identity with FLRT1 and 44% identity with FLRT2. FLRT3 is expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.