HIST1H2BI

Histone cluster 1, H2bi
250px PDB rendering based on 1aoi.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3A6N, 3AFA, 3AN2, 3AV1, 3AV2, 3AYW, 3AZE, 3AZF, 3AZG, 3AZH, 3AZI, 3AZJ, 3AZK, 3AZL, 3AZM, 3AZN
Identifiers
Symbols	HIST1H2BI ; H2B/k; H2BFK
External IDs	OMIM: 602807 HomoloGene: 135944 GeneCards: HIST1H2BI Gene
Gene ontology Molecular function • DNA binding • protein binding • protein heterodimerization activity Cellular component • nucleosome • nuclear nucleosome • extracellular space • nucleus • nucleoplasm • extracellular exosome Biological process • innate immune response in mucosa • chromatin organization • nucleosome assembly • antibacterial humoral response • defense response to Gram-positive bacterium Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8346	68024
Ensembl	ENSG00000278588	ENSMUSG00000018102
UniProt	P62807	Q6ZWY9
RefSeq (mRNA)	NM_003525	NM_001290380
RefSeq (protein)	NP_003516	NP_001277309
Location (UCSC)	Chr 6: 26.27 – 26.27 Mb	Chr 13: 23.57 – 23.57 Mb
PubMed search	[1]	[2]

Histone H2B type 1-C/E/F/G/I is a protein that in humans is encoded by the HIST1H2BI gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.