Heat shock protein 47
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Heat shock protein 47, also known as SERPINH1 is a serpin which serves as a human chaperone protein for collagen.[1][2]
Function
This protein is a member of the serpin superfamily of serine proteinase inhibitors. Its expression is induced by heat shock. The protein localizes to the endoplasmic reticulum lumen and binds collagen; thus it is thought to be a molecular chaperone involved in the maturation of collagen molecules. Autoantibodies to this protein have been found in patients with rheumatoid arthritis.[1]
Interactions
Heat shock protein 47 has been shown to interact with collagens I, II, III, IV and V.[3]
References
Further reading
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External links
- The MEROPS online database for peptidases and their inhibitors: I04.035
- HSP47 Heat-Shock Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
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