mir-124 microRNA precursor family

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miR-124 microRNA precursor family
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Predicted secondary structure and sequence conservation of mir-124
Identifiers
Symbol mir-124
Rfam RF00239
miRBase MI0000443
miRBase family MIPF0000021
Other data
RNA type Gene; miRNA
Domain(s) Eukaryota
GO 0035195 0035068
SO 0001244

The miR-124 microRNA precursor is a small non-coding RNA molecule that has been identified in flies (MI0000373),[1] nematode worms (MI0000302),[2] mouse (MI0000150) and human (MI0000443).[3] The mature ~21 nucleotide microRNAs are processed from hairpin precursor sequences by the Dicer enzyme, and in this case originates from the 3' arm. miR-124 has been found to be the most abundant microRNA expressed in neuronal cells. Experiments to alter expression of miR-124 in neural cells did not appear to affect differentiation.[4] However these results are controversial since other reports have described a role for miR-124 during neuronal differentiation.[5]

Targets of miR-124

  • Visvanathan et al.. showed that miR-124 targets the mRNA of the anti-neural function protein SCP1 (small C-terminal domain phosphatase 1).[6]
  • Makeyev et al. showed that miR-124 directly targets PTBP1 (PTB/hnRNP I) mRNA, which encodes a global repressor of alternative pre-mRNA splicing in non-neuronal cells.[7]
  • Arrant et al. wrote that miR-124 changes glutamate receptor composition in the prefrontal cortex and can decrease social dysfunction in frontotemporal dementia.[8]

References

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External links


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