PIGP

Phosphatidylinositol glycan anchor biosynthesis, class P
Identifiers
Symbols	PIGP ; DCRC; DCRC-S; DSCR5; DSRC
External IDs	OMIM: 605938 MGI: 1860433 HomoloGene: 32444 GeneCards: PIGP Gene
EC number	2.4.1.198
Gene ontology Molecular function • phosphatidylinositol N-acetylglucosaminyltransferase activity Cellular component • glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex • endoplasmic reticulum membrane • integral component of membrane Biological process • C-terminal protein lipidation • preassembly of GPI anchor in ER membrane • post-translational protein modification • cellular protein metabolic process Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE PIGP 221689 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51227	56176
Ensembl	ENSG00000185808	ENSMUSG00000022940
UniProt	P57054	Q9JHG1
RefSeq (mRNA)	NM_153681	NM_001159616
RefSeq (protein)	NP_710148	NP_001153088
Location (UCSC)	Chr 21: 37.06 – 37.07 Mb	Chr 16: 94.36 – 94.37 Mb
PubMed search	[1]	[2]

Subunit P of phosphatidylinositol N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the PIGP gene.

This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.