Plasminogen activator

Fibrinolysis

A plasminogen activator is a serine protease which converts plasminogen to plasmin, thus promoting fibrinolysis.

Types include:

• Tissue plasminogen activator
• Urokinase

It is inhibited by plasminogen activator inhibitor-1 and plasminogen activator inhibitor-2.

Plasminogen
PDB rendering based on 4dur.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1B2I, 1BML, 1BUI, 1CEA, 1CEB, 1DDJ, 1HPJ, 1HPK, 1I5K, 1KI0, 1KRN, 1L4D, 1L4Z, 1PK4, 1PKR, 1PMK, 1QRZ, 1RJX, 2DOH, 2DOI, 2KNF, 2L0S, 2PK4, 3UIR, 4A5T, 4CIK, 4DCB, 4DUR, 4DUU, 5HPG
Identifiers
Symbols	PLG ; DKFZp779M0222
External IDs	OMIM: 173350 MGI: 97620 HomoloGene: 55452 ChEMBL: 1801 GeneCards: PLG Gene
EC number	3.4.21.7
Gene ontology Molecular function • serine-type endopeptidase activity • receptor binding • protein binding • serine-type peptidase activity • protein domain specific binding • apolipoprotein binding Cellular component • extracellular region • extracellular space • plasma membrane • cell surface • platelet alpha granule lumen • extrinsic component of external side of plasma membrane • extracellular exosome • blood microparticle Biological process • platelet degranulation • proteolysis • blood coagulation • negative regulation of cell proliferation • negative regulation of cell-substrate adhesion • extracellular matrix disassembly • platelet activation • extracellular matrix organization • fibrinolysis • cellular protein metabolic process • tissue remodeling • negative regulation of fibrinolysis • positive regulation of fibrinolysis • negative regulation of cell-cell adhesion mediated by cadherin Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5340	18815
Ensembl	ENSG00000122194	ENSMUSG00000059481
UniProt	P00747	P20918
RefSeq (mRNA)	NM_000301	NM_008877
RefSeq (protein)	NP_000292	NP_032903
Location (UCSC)	Chr 6: 160.7 – 160.75 Mb	Chr 17: 12.38 – 12.42 Mb
PubMed search	[1]	[2]