SCN3B
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Sodium channel subunit beta-3 is a protein that in humans is encoded by the SCN3B gene.[1][2] Two alternatively spliced variants, encoding the same protein, have been identified.
Contents
Function
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel.[2]
Clinical significance
Mutations in the gene are associated with abnormal cardiac electrophysiology.[3][4]
See also
References
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External links
- GeneReviews/NIH/NCBI/UW entry on Brugada syndrome
- SCNB3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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