SPRY4

Sprouty RTK signaling antagonist 4
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3BUN
Identifiers
Symbols	SPRY4 ; HH17
External IDs	OMIM: 607984 MGI: 1345144 HomoloGene: 8042 GeneCards: SPRY4 Gene
Gene ontology Molecular function • protein binding Cellular component • cytoplasm • Golgi apparatus • focal adhesion • ruffle membrane Biological process • multicellular organismal development • negative regulation of ERK1 and ERK2 cascade Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE SPRY4 221489 s at tn.png
File:PBB GE SPRY4 gnf1h07924 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	81848	24066
Ensembl	ENSG00000187678	ENSMUSG00000024427
UniProt	Q9C004	Q9WTP2
RefSeq (mRNA)	NM_001127496	NM_011898
RefSeq (protein)	NP_001120968	NP_036028
Location (UCSC)	Chr 5: 142.31 – 142.33 Mb	Chr 18: 38.59 – 38.6 Mb
PubMed search	[1]	[2]

Protein sprouty homolog 4 is a protein that in humans is encoded by the SPRY4 gene.

Function

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002).[supplied by OMIM]

See also

• MAPK signaling pathway
• Ras subfamily

Interactions

SPRY4 has been shown to interact with TESK1.