Template:PBB/3481

Insulin-like growth factor 2
PDB rendering based on 1igl.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1GF2, 1IGL, 2L29, 2V5P, 3E4Z, 3KR3
Identifiers
Symbols	IGF2 ; C11orf43; IGF-II; PP9974
External IDs	OMIM: 147470 MGI: 96434 HomoloGene: 510 GeneCards: IGF2 Gene
Gene ontology Molecular function • insulin receptor binding • insulin-like growth factor receptor binding • hormone activity • protein binding • growth factor activity • receptor activator activity • protein serine/threonine kinase activator activity Cellular component • extracellular region • extracellular space • plasma membrane • platelet alpha granule lumen • extracellular exosome Biological process • skeletal system development • ossification • positive regulation of protein phosphorylation • platelet degranulation • glucose metabolic process • regulation of gene expression by genetic imprinting • regulation of transcription, DNA-templated • multicellular organismal development • blood coagulation • positive regulation of cell proliferation • insulin receptor signaling pathway • organ morphogenesis • platelet activation • exocrine pancreas development • insulin receptor signaling pathway via phosphatidylinositol 3-kinase • positive regulation of activated T cell proliferation • positive regulation of catalytic activity • positive regulation of MAPK cascade • cellular protein metabolic process • positive regulation of glycogen biosynthetic process • positive regulation of mitotic nuclear division • positive regulation of transcription from RNA polymerase II promoter • positive regulation of insulin receptor signaling pathway • positive regulation of peptidyl-tyrosine phosphorylation • striated muscle cell differentiation • positive regulation of protein kinase B signaling • positive regulation of protein serine/threonine kinase activity • positive regulation of receptor activity • positive regulation of glycogen (starch) synthase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3481	16002
Ensembl	ENSG00000167244	ENSMUSG00000048583
UniProt	P01344	P09535
RefSeq (mRNA)	NM_000612	NM_001122736
RefSeq (protein)	NP_000603	NP_001116208
Location (UCSC)	Chr 11: 2.13 – 2.15 Mb	Chr 7: 142.65 – 142.67 Mb
PubMed search	[1]	[2]