Template:PBB/3952

Leptin
PDB rendering based on 1ax8.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1AX8
Identifiers
Symbols	LEP ; LEPD; OB; OBS
External IDs	OMIM: 164160 MGI: 104663 HomoloGene: 193 GeneCards: LEP Gene
Gene ontology Molecular function • hormone activity • growth factor activity • peptide hormone receptor binding Cellular component • extracellular region • extracellular space • cytoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • ovulation from ovarian follicle • response to hypoxia • positive regulation of cytokine production • placenta development • response to dietary excess • cardiac muscle hypertrophy • glucose metabolic process • regulation of gluconeogenesis • energy reserve metabolic process • glycerol biosynthetic process • fatty acid beta-oxidation • tyrosine phosphorylation of STAT protein • female pregnancy • circadian rhythm • cholesterol metabolic process • bile acid metabolic process • regulation of blood pressure • positive regulation of cell proliferation • adult feeding behavior • central nervous system neuron development • insulin secretion • regulation of intestinal cholesterol absorption • negative regulation of appetite • response to insulin • response to vitamin E • leptin-mediated signaling pathway • positive regulation of luteinizing hormone secretion • positive regulation of peroxisome proliferator activated receptor signaling pathway • bone mineralization involved in bone maturation • hormone metabolic process • positive regulation of tyrosine phosphorylation of Stat3 protein • glucose homeostasis • eating behavior • negative regulation of apoptotic process • positive regulation of ion transport • positive regulation of MAPK cascade • regulation of fat cell differentiation • positive regulation of myeloid cell differentiation • negative regulation of vasoconstriction • positive regulation of insulin receptor signaling pathway • positive regulation of follicle-stimulating hormone secretion • positive regulation of developmental growth • regulation of insulin secretion • regulation of steroid biosynthetic process • leukocyte tethering or rolling • regulation of lipoprotein lipid oxidation • adipose tissue development • negative regulation of cartilage development • negative regulation of glucagon secretion • cellular response to L-ascorbic acid • cellular response to retinoic acid • positive regulation of STAT protein import into nucleus • positive regulation of reactive oxygen species metabolic process • negative regulation of glutamine transport • positive regulation of hepatic stellate cell activation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3952	16846
Ensembl	ENSG00000174697	ENSMUSG00000059201
UniProt	P41159	P41160
RefSeq (mRNA)	NM_000230	NM_008493
RefSeq (protein)	NP_000221	NP_032519
Location (UCSC)	Chr 7: 128.24 – 128.26 Mb	Chr 6: 29.06 – 29.07 Mb
PubMed search	[1]	[2]