SLC10A1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Sodium/bile acid cotransporter also known as the Na+-taurocholate cotransporting polypeptide (NTCP) or liver bile acid transporter (LBAT) is a protein that in humans is encoded by the SLC10A1 (solute carrier family 10 member 1) gene.[1][2]
Structure
Sodium/bile acid cotransporters are integral membrane glycoproteins. Human NTCP contains 349 amino acids and has a mass of 56 kDa.[3]
Function
Bile acid:sodium symporters participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids. One of these absorbs bile acids from the intestinal lumen, the bile duct, and the kidney with an apical localization (ileal sodium/bile acid cotransporter). The other is this protein and is expressed in the basolateral membranes of hepatocytes (NTCP).[3]
As a cotransporter, NTCP binds two sodium ions and one (conjugated) bile salt molecule, thereby providing an hepatic influx of bile salts. Other transported molecules include steroid hormones, thyroid hormones and various xenobiotics: [3]
Hepatitis virus entry
NTCP is a cell surface receptor necessary for the entry of hepatitis B and hepatitis D virus.[4] This entry mechanism is inhibited by myrcludex B,[5] cyclosporin A, progesterone, propranolol, bosentan, ezetimibe, as well as NTCP substrates like taurocholate, tauroursodeoxycholate and bromosulfophthalein.[3]
See also
References
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Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
