U2AF2
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Splicing factor U2AF 65 kDa subunit is a protein that in humans is encoded by the U2AF2 gene.[1]
Function
U2 auxiliary factor (U2AF), composed of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit, which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple alternatively spliced transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date.[2]
Interactions
U2AF2 has been shown to interact with:
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References
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Further reading
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