U2 small nuclear RNA auxiliary factor 1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Splicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the U2AF1 gene.[1][2][3]
Function
This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]
Interactions
U2 small nuclear RNA auxiliary factor 1 has been shown to interact with:
References
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Further reading
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