PDGFRB
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Beta-type platelet-derived growth factor receptor is a protein that in humans is encoded by the PDGFRB gene.
Function
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5q- syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.[1]
Interactions
PDGFRB has been shown to interact with:
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See also
References
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Further reading
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External links
- CD140B Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
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