Langerin

CD207, langerin (Cluster of Differentiation 207) is a protein which in humans is encoded by the CD207 gene. Langerin is a type II transmembrane, C-type lectin receptor on Langerhans cells.

Function

The protein encoded by this gene is expressed in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. Additionally it is known by the name C-type lectin domain family 4 member K (CD antigen CD207). It is also expressed in several other dendritic cell types including dermal CD103+ DCs and splenic CD8+ DCs. Langerin is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway.

Clinical significance

Langerin on mucosal Langerhans cells of the human genital epithelium binds to HIV-1 and subsequently internalizes it into Birbeck granules to be degraded.

See also

• Paul Langerhans
• Langerhans cell

External links

• CD207 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)