3-Iodothyronamine
Names | |
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IUPAC name
4-[4-(2-Amino-ethyl)-2-iodo-phenoxy]-phenol
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Other names
T1AM
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Identifiers | |
712349-95-6 | |
ChemSpider | 8126125 |
Jmol 3D model | Interactive image Interactive image |
PubChem | 9950514 |
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Properties | |
C14H14INO2 | |
Molar mass | 355.17 g/mol |
Vapor pressure | {{{value}}} |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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verify (what is ?) | |
Infobox references | |
3-Iodothyronamine (T1AM) is an endogenous thyronamine. T1AM is a high-affinity ligand for the trace amine-associated receptor TAAR1 (TAR1, TA1), a recently discovered G protein-coupled receptor.[1][2] T1AM is the most potent endogenous TAAR1 agonist yet discovered.[3] Activation of TAAR1 by T1AM results in the production of large amounts of cAMP. This effect is coupled with decreased body temperature and cardiac output.[4] Wu et al. have pointed out that this relationship is not typical of the endocrine system, indicating that TAAR1 activity may not be coupled to G-proteins in some tissues, or that T1AM may interact with other receptor subtypes.[3]
T1AM may be part of a signaling pathway to modulate cardiac function, as the compound can induce negative inotropic effects and decrease cardiac output.[5]
See also
External links
- 3-iodothyronamine at the US National Library of Medicine Medical Subject Headings (MeSH)
References
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- Articles without EBI source
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- Chemical articles using a fixed chemical formula
- Biogenic amines
- Iodinated tyrosine derivatives
- Phenol ethers
- Phenethylamines
- Thyroid
- TAAR1 agonists
- Trace amines