Levocabastine

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Levocabastine
Levocabastine.svg
Systematic (IUPAC) name
(3S,4R)-1-[cis-4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-4-piperidinecarboxylic acid
Clinical data
Trade names Livostin
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pregnancy
category
  • AU: B3
  • US: C (Risk not ruled out)
Legal status
  • ℞ (Prescription only)
Routes of
administration
Ophthalmic, intranasal[1]
Identifiers
CAS Number 79516-68-0 YesY
ATC code R01AC02 (WHO) S01GX02
PubChem CID: 54385
IUPHAR/BPS 1586
DrugBank DB01106 YesY
ChemSpider 16736421 YesY
UNII H68BP06S81 YesY
KEGG D08117 YesY
ChEMBL CHEMBL1201312 N
Chemical data
Formula C26H29FN2O2
Molecular mass 420.519 g/mol
  • Fc1ccc(cc1)[C@]2(CC[C@@H](CC2)N3CC[C@@]([C@H](C)C3)(c4ccccc4)C(O)=O)C#N
  • InChI=1S/C26H29FN2O2/c1-19-17-29(16-15-26(19,24(30)31)21-5-3-2-4-6-21)23-11-13-25(18-28,14-12-23)20-7-9-22(27)10-8-20/h2-10,19,23H,11-17H2,1H3,(H,30,31)/t19-,23-,25-,26-/m1/s1 YesY
  • Key:ZCGOMHNNNFPNMX-KYTRFIICSA-N YesY
 NYesY (what is this?)  (verify)

Levocabastine (trade name Livostin) is a selective second-generation H1 receptor antagonists which was discovered at Janssen Pharmaceutica in 1979. It is used for allergic conjunctivitis.[2]

As well as acting as an antihistamine, levocabastine has also subsequently been found to act as a potent and selective antagonist for the neurotensin receptor NTS2, and was the first drug used to characterise the different neurotensin subtypes.[3][4] This has made it a useful tool for the study of this receptor.[5][6][7][8][9]

The pharmaceutical drug Bilina is a combination of Levocabastine, benzalkonium chloride, and other components and is typically used in a 0.5 mg/ml suspension as eye-drops, dispensed in 4ml bottles for the treatment of allergic conjunctivitis or similar allergic ocular conditions.[10]

References

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External links

  1. REDIRECT Template:Peptide receptor modulators

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