Lupitidine

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Lupitidine (code name SK&F 93479) is a long-acting H2 receptor antagonist[1] described as an antiulcer agent. It was shown to inhibit nocturnal gastric acid secretion[2] and, in experiments on rodents, produced diffuse neuroendocrine cell hyperplasia and an increase in multifocal glandular hyperplasia due to hypergastrinemia resulting from the pharmacological suppression of gastric acid secretion.[3]

Synthesis[4]

500 px

References

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  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Lam, B. L.; Pridgen, L. N.; 1982, U.S. Patent 4,352,933
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