NKX6-2

NK6 homeobox 2
NK6 homeobox 2
Identifiers
Symbols	NKX6-2 ; GTX; NKX6.2; NKX6B
External IDs	OMIM: 605955 MGI: 1352738 HomoloGene: 18580 GeneCards: NKX6-2 Gene
Gene ontology
Molecular function	• RNA polymerase II core promoter proximal region sequence-specific DNA binding; • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; • transcription factor activity, sequence-specific DNA binding;
Cellular component	• nucleus;
Biological process	• negative regulation of transcription from RNA polymerase II promoter; • regulation of transcription, DNA-templated; • negative regulation of cell fate commitment; • positive regulation of cell fate commitment; • regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification; • regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification; • central nervous system myelination; • endocrine pancreas development; • negative regulation of glial cell differentiation; • positive regulation of glial cell differentiation; • neuromuscular process controlling balance;
	Sources: Amigo / QuickGO
Orthologs
Species	Human
Entrez	84504
Ensembl	ENSG00000148826
UniProt	Q9C056
RefSeq (mRNA)	NM_177400
RefSeq (protein)	NP_796374
Location (UCSC)	Chr 10:; 132.78 – 132.79 Mb
PubMed search	[1]
	v; t; e;

Homeobox protein Nkx-6.2 is a protein that in humans is encoded by the NKX6-2 gene.^[1]^[2]

References