Platelet-activating factor receptor
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The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor.[1][2]
The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM][3] Its pathogenetic role in chronic kidney failure has also been reported recently. [4]
Ligands
Agonists
Antagonists
- Israpafant (Y-24180)
- WEB 2086
References
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Further reading
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External links
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- platelet activating factor receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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