Tachykinin receptor

There are three known mammalian tachykinin receptors termed NK₁, NK₂ and NK₃. All are members of the 7 transmembrane G-protein coupled receptor family and induce the activation of phospholipase C, producing inositol triphosphate (so called G_q-coupled).

Binding

The genes and receptor ligands are as follows:

Receptor	Gene	Preferred ligand
NK1	TACR1	substance P
NK2	TACR2	neurokinin A
NK3	TACR3	neurokinin B

(Hökfelt et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000)

See also

• Substance P
• G protein coupled receptors

External links

• Tachykinin Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)