XCT790
From Infogalactic: the planetary knowledge core
Names | |
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IUPAC name
(2E)-3-(4-{[2,4-bis(trifluoromethyl)benzyl]oxy}-3-methoxyphenyl)-2-cyano-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acrylamide
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Identifiers | |
725247-18-7 | |
ChEMBL | ChEMBL189753 |
ChemSpider | 5293979 |
2832 | |
Jmol 3D model | Interactive image |
PubChem | 6918788 |
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Properties | |
C23H13F9N4O3S | |
Molar mass | 596.424949 |
Vapor pressure | {{{value}}} |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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verify (what is ?) | |
Infobox references | |
XCT790 is a potent and selective inverse agonist ligand of the estrogen-related receptor alpha.[1] Independent of its inhibition of ERRα, XCT790 is a potent mitochondrial electron transport chain uncoupler. [2]
Mitochondrial electron transport chain uncoupling effect
XCT790 has been shown to uncouple oxygen consumption from ATP production in mitochondria at very low, nanomolar-range doses independently of ERRα expression. Its effects are similar to proton ionophores such as FCCP, which disrupt mitochondrial transmembrane electrochemical gradients. This uncoupling leads to a fast drop in ATP production and, consequently, a prompt activation of AMPK.[2]
References
External links
- XCT790 at the US National Library of Medicine Medical Subject Headings (MeSH)
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