SIX4

SIX homeobox 4
Identifiers
Symbols	SIX4 ; AREC3
External IDs	OMIM: 606342 MGI: 106034 HomoloGene: 69089 GeneCards: SIX4 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Cellular component • nucleus • cytoplasm Biological process • transcription from RNA polymerase II promoter • skeletal muscle tissue development • regulation of synaptic growth at neuromuscular junction • male gonad development • anatomical structure morphogenesis • male sex determination • olfactory placode formation • regulation of protein localization • protein localization to nucleus • inner ear morphogenesis • negative regulation of apoptotic process • negative regulation of neuron apoptotic process • tongue development • sarcomere organization • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • male sex differentiation • thymus development • generation of neurons • embryonic cranial skeleton morphogenesis • regulation of epithelial cell proliferation • myoblast migration • pharyngeal system development • myotome development • fungiform papilla morphogenesis • trigeminal ganglion development • metanephric mesenchyme development • regulation of branch elongation involved in ureteric bud branching • positive regulation of ureteric bud formation • positive regulation of branching involved in ureteric bud morphogenesis • skeletal muscle fiber differentiation • negative regulation of satellite cell differentiation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51804	20474
Ensembl	ENSG00000100625	ENSMUSG00000034460
UniProt	Q9UIU6	Q61321
RefSeq (mRNA)	NM_017420	NM_011382
RefSeq (protein)	NP_059116	NP_035512
Location (UCSC)	Chr 14: 60.71 – 60.72 Mb	Chr 12: 73.1 – 73.11 Mb
PubMed search	[1]	[2]

Homeobox protein SIX4 is a protein that in humans is encoded by the SIX4 gene.