ZNF423

Zinc finger protein 423
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2MDG
Identifiers
Symbols	ZNF423 ; Ebfaz; JBTS19; NPHP14; OAZ; Roaz; ZFP423; Zfp104; hOAZ
External IDs	OMIM: 604557 MGI: 1891217 HomoloGene: 9010 GeneCards: ZNF423 Gene
Gene ontology Molecular function • DNA binding • protein binding • metal ion binding Cellular component • nucleus Biological process • transcription, DNA-templated • Notch signaling pathway • nervous system development • cell differentiation • positive regulation of BMP signaling pathway • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23090	94187
Ensembl	ENSG00000102935	ENSMUSG00000045333
UniProt	Q2M1K9	Q80TS5
RefSeq (mRNA)	NM_001271620	NM_033327
RefSeq (protein)	NP_001258549	NP_201584
Location (UCSC)	Chr 16: 49.49 – 49.86 Mb	Chr 8: 87.66 – 87.96 Mb
PubMed search	[1]	[2]

Zinc finger protein 423 is a protein that in humans is encoded by the ZNF423 gene.

The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development.

Interactions

ZNF423 has been shown to interact with EBF1 and PARP1.

External links

• OAZ protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.