Zinc finger and BTB domain-containing protein 16
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene.
Function
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL)[1] and physiological roles have been identified in mouse Natural Killer T cells[2][3] and gamma-delta T cells.[4] Alternate transcriptional splice variants have been characterized in human.[5][6]
Interactions
Zinc finger and BTB domain-containing protein 16 has been shown to interact with:
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- Angiotensin II receptor type 1,[7]
- BCL6,[8]
- BMI1,[9]
- Calcitriol receptor,[10][11]
- FHL2,[12]
- GATA1,[13]
- GATA2,[14]
- HDAC1,[15][16][17]
- HDAC4,[15][18]
- HDAC6,[15]
- Heparin-binding EGF-like growth factor,[19][20]
- Histone deacetylase 5,[15][18]
- Nuclear receptor co-repressor 2,[17][21][22]
- Promyelocytic leukemia protein[23]
- RUNX1T1,[24][25]
- Retinoic acid receptor alpha,[26]
- SIN3A,[10][16][17]
- SIN3B,[16] and
- ZBTB32.[27]
See also
References
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Further reading
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External links
- ZBTB16 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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