Lidoflazine
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Systematic (IUPAC) name | |
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2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]-N-(2,6-dimethylphenyl)acetamide
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Clinical data | |
AHFS/Drugs.com | International Drug Names |
Identifiers | |
CAS Number | 3416-26-0 |
ATC code | C08EX01 (WHO) |
PubChem | CID: 3926 |
ChemSpider | 3789 |
UNII | J4ZHN3HBTE |
KEGG | D04733 |
Chemical data | |
Formula | C30H35F2N3O |
Molecular mass | 491.615 g/mol |
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Physical data | |
Melting point | 159 to 161 °C (318 to 322 °F) |
Solubility in water | Almost insoluble in water(<0.01%); Very soluble in chloroform(>50%); mg/mL (20 °C) |
(what is this?) (verify) |
Lidoflazine is a piperazine calcium channel blocker. It is a coronary vasodilator with some antiarrhythmic action.[1] Lidoflazine was discovered at Janssen Pharmaceutica in 1964.
Physical properties
Solubility at room temperature
Extracted from [2]
Solvent | 0.01
N |
0.1
N |
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% | pH | % | pH | |
Hydrochloric Acid | 0.4 | 3.0 | 0.7 | 1.9 |
Tartaric Acid | 0.3 | 3.1 | 1.0 | 2.5 |
Citric Acid | 0.3 | 3.1 | 0.5 | 2.5 |
Lactic Acid | 0.2 | 3.4 | 0.7 | 2.9 |
Acetic Acid | 0.1 | 3.5 | 0.4 | 3.8 |
References
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ http://jpet.aspetjournals.org/cgi/content/abstract/152/2/265
- Schaper WK, Xhonneux R, Jageneau AH., Stimulation of the coronary collateral circulation by lidoflazine (R 7904), Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1965 November 4;252(1):1-8.
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Categories:
- Chemical articles having calculated molecular weight overwritten
- Articles with changed InChI identifier
- Infobox drug articles without a structure image
- Articles without EBI source
- Chemical pages without DrugBank identifier
- Drugs with no legal status
- Piperazines
- Calcium channel blockers
- Acetanilides
- Organofluorides
- Janssen Pharmaceutica
- Belgian inventions
- Cardiovascular system drug stubs