YM-348

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YM-348
YM-348 structure.png
Systematic (IUPAC) name
(2S)-​1-​(7-​ethyl-​1H-​furo[2,3-g]indazol-​1-​yl)propan-​2-​amine
Identifiers
CAS Number 372163-84-3
PubChem CID: 3045225
IUPHAR/BPS 230
ChemSpider 2308001
Chemical data
Formula C14H17N3O
Molecular mass 243.31 g·mol−1
  • n3cc2ccc1oc(cc1c2n3C[C@@H](N)C)CC
  • InChI=1S/C14H17N3O/c1-3-11-6-12-13(18-11)5-4-10-7-16-17(14(10)12)8-9(2)15/h4-7,9H,3,8,15H2,1-2H3/t9-/m0/s1
  • Key:QLOOWOVVZLBYHU-VIFPVBQESA-N
  (verify)

YM-348 is an indazole derivative drug which acts as a potent and selective 5-HT2C receptor agonist, with an EC50 of 1nM and 15x selectivity over 5-HT2A, although it only has moderate selectivity of 3x over the closely related 5-HT2B receptor.[1][2] It has thermogenic and anorectic effects in animal studies, making it potentially useful for the treatment of obesity.[3][4][5][6]

See also

References

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