Estropipate

"Ogen" redirects here. For the character in the Japanese anime, see Ogen (Basilisk).

Estropipate (INN, BAN) (brand names Ogen, Ortho-Est), also known as piperazine estrone sulfate, is a synthetic, steroidal estrogen. It is a salt of estrone sulfate and piperazine.

Uses

Estropipate is used to:

• Alleviate symptoms of menopause as hormone replacement therapy
• Treat some types of infertility
• Treat some conditions leading to underdevelopment of female sexual characteristics
• Treat vaginal atrophy
• Treat some types of breast cancer (particularly in men and postmenopausal women)
• Treat prostate cancer
• Prevent osteoporosis

Pharmacology

Estropipate is an agonist of the estrogen receptor (ER). In addition, estropipate has been found to act as an inhibitor of OATP1B1 (IC₅₀ = 70 nM).[1]

See also

• Estrogen ester