PF-610355
Systematic (IUPAC) name | |
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N-[(4'-Hydroxy-3-biphenylyl)methyl]-2-[3-(2-{[(2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl]amino}-2-methylpropyl)phenyl]acetamide
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Clinical data | |
Legal status |
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Routes of administration |
Inhalation |
Identifiers | |
CAS Number | 862541-45-5 |
ATC code | None |
PubChem | CID: 11505444 |
ChemSpider | 9680243 |
UNII | ZH5SMU97AJ |
ChEMBL | CHEMBL1240967 |
Chemical data | |
Formula | C34H39N3O6S |
Molecular mass | 617.76 g·mol−1 |
PF-610355 (also known as PF-00610355 or PF-610,355) is an inhalable[1] ultra-long-acting β2 adrenoreceptor agonist[2] (ultra-LABA) that was investigated as a treatment of asthma and COPD by Pfizer.[3] It utilizes a sulfonamide agonist headgroup, that confers high levels of intrinsic crystallinity that could relate to the acidic sulfonamide motif supporting a zwitterionic form in the solid state. Optimization of pharmacokinetic properties minimized systemic exposure following inhalation and reduced systemically-mediated adverse events.[4] Its in vivo duration on action confirmed its potential for once-daily use in humans.[5]
The investigation and development of PF-610355 were discontinued in 2011,[6] likely for strategic and regulatory reasons.[7]
References
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